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Potential risk factors were higher age of the patient, HPS administration by home community nurses, and the number of prior CRBSIs. ( 4), cancer as the underlying diagnosis to chronic IF did not demonstrate a statistically significant increase in HR for developing CRBSIs. In another study from our IF unit, by Brandt et al. The great majority of our patients who experience chronic IF because of cancer do not receive cancer treatment while receiving HPS. We do not use double-lumen tunneled CVCs in our IF-HPS unit, and we do tend to replace total implantable ports to tunneled single-lumen CVCs when patients are initiated on HPS. In total, 2885 CVCs were used 2006 (69.5%) were single-lumen, subcutaneously tunneled CVCs 869 (30.1%) were short-term nontunneled CVCs, which were not evaluated in relation to our CVC salvage protocol and only 10 (0.3%) were total implantable ports. The distribution of the different types of central venous access devices in our HPS population is presented in Table 1 in our article ( 1). The number and percentage of patients without an elevated WBC, unfortunately, were not registered in our database. We have methodically evaluated all diagnoses of CRBSIs in our database according to different microbiological diagnostic criteria ( 3). According to the Copenhagen Intestinal Failure (IF) database, as stated in the article ( 1), a CRBSI is defined by the presence of clinical and paraclinical evidence supporting systemic infection: elevation of C-reactive protein or WBC and positive qualitative blood cultures from the central venous catheter (CVC) or from a peripheral vein, with no other proven focus of the infection. ( 2) that elevation in white blood cell (WBC) count is not mandatory to qualify for the diagnosis of a CRBSI. Alan L Buchman for the interest in our retrospective database study evaluating our catheter salvage protocol in relation to catheter-related bloodstream infections (CRBSIs) in home parenteral support (HPS) patients assessing the short- and long-term consequences and potential microbial risk factors ( 1).